CAS  STZ-diabetic rats were treated orally with ZZRext (200, 300 mg/kg per … The digestive system: absorption of alcohol. (EtOH: ethanol; 200 + EtOH: 200 mg/kg extract + ethanol; 400 + EtOH: 400 mg/kg extract + ethanol). Necropsy examinations of chronic alcoholics have shown a variety of structural and functional alterations in the neurons [10]. The ethanol extract from the rhizome of Zingiber zerumbet (L.) Smith (EEZZR) has been indicated to possess an insulin-like property by ameliorating hyperglycemia in diabetes. Article  This was shown by increased in both antioxidant SOD and GSH level and reduction of both homogenate and plasma MDA, plasma protein carbonyl, and renal advanced oxidation protein product (AOPP) than those in the paracetamol induced group [17]. Effects of chronic ethanol exposure on renal function tests and oxidative stress in kidney. 2007;104(3):1183–91. Serum samples were stored at − 20 °C for subsequent biochemical analysis. Impairment in GSH cellular defence mechanisms leads to the development of oxidative stress [38]. Harrison-Findik DD, Lu S. The effect of alcohol and hydrogen peroxide on liver hepcidin gene expression in mice lacking antioxidant enzymes, glutathione peroxidase-1 or catalase. Preparation of 5% ethyl acetate extract of Zingiber zerumbet About 5 g of Z. zerumbet rhizome extract (ZZRE) extract was dissolved in 5 mL of dimethyl sulfoxide with ratio of 1:1. http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, https://doi.org/10.1186/s12906-018-2161-5. In addition, cerebral cortex is the outermost layer of the cerebrum and contains billion of neurons that play a role in memory, intelligence and muscle movement [31]. [17] also reported that ethyl-acetate extract of Z. zerumbet could increase SOD and GSH activities in paracetamol-induced hepatotoxicity and nephrotoxicity in rats. Part of The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. 2g). Zingiber zerumbet Sm., locally known to the Malay as “Lempoyang,” is a perennial herb found in many tropical countries, including Malaysia. [18] and Abdul Hamid et al. Administration of ethanol for 14 days induced oxidative stress as evidenced by a significant reduction (p < 0.05) of SOD, CAT and GPx enzyme activities (Fig. Note the number and shape of neuron cells. Administration of ethanol alone caused a significant increase (p < 0.05) in protein carbonyl level in the brain samples compared to the normal group. 2012. Microscopic structures of the brain (cerebellum and cortex cerebrum) from normal, ethanol, 200 mg/kg + ethanol, and 400 mg/kg + ethanol groups were observed as presented in Figs. Maralla S, Reddy KS. 1986) [23]. The rhizomes of Z. zerumbet are used to treat ulcerative colitis [19] to cure dyspepsia wound, hemorrhoids, and stomach discomfort [20]. Figure 3a showed that no histological changes were observed in the normal, 200 mg/kg + ethanol, and 400 mg/kg + ethanol groups as evidenced by normal Purkinje cells in the cerebellum (Fig. The role of oxidative stress in fetal alcohol spectrum disorders. GPx enzyme is responsible for detoxifying H2O2 by converting it to H2O in which GSH acts as an electron donor in this reaction [37]. 1a). Some probably aren't as safe as you'd hope. Environmental Working Group. About the Experts. Paglia DE, Valentine WN. 2012;7(3):81–8. Anti-aging Agents (1) Anti-inflammatories (1) Conditioning Agents (1) Healing Agents (1) Learn more | Legal Disclaimer, Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. NLM (National Library of Medicine). Arch Biochem Biophys. CAS  Mansouri A, Demeilliers C, Amsellem S, Pessayre D, Fromenty B. Most probably, the 200 mg/kg of Z. zerumbet extract was insufficient to overcome the ROS generated by the ethanol induction. This indicates that the amount of antioxidant compounds present in Z. zerumbet contributes significantly to its antioxidant property [18]. FEBS Lett. Values are expressed as mean ± SEM. 2007; https://doi.org/10.1186/1475-2867-7-4. Thus, the aim of this study is to investigate the protective effects of the ethyl-acetate extract of Z. zerumbet rhizomes against ethanol-induced brain damage in male Wistar rats. Pharmacology. Note the number of Purkinje cells. Dose-Response Relationship of Zerumbone in Rat with … In addition, an increase in the antioxidant activity can be described as an adaptive response to excessive ROS [42]. We would like to thank our colleagues from Biomedical Science Programme, Centre of Health & Applied Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia who provided insight and expertise that greatly assisted the research. Copyright © 2020. a Effects of Z. zerumbet extract on malondialdehyde level. Thus, it could be speculated that Z. zerumbet extract may induce GSH synthesis by protecting the brain against ethanol-induced damage through similar mechanism. (FSK/BIOMED/2012/ASMAH/21-NOV/475-NOV-2012-JUNE-2013). Butterfield DA, Castegna A, Drake J, Scapagnini G, Calabrese V. Vitamin E and neurodegenerative disorders associated with oxidative stress. Kizaherbs Sdn Bhd ) in ethanol-induced group as compared to a lower dose of 200 of... All datasets used and/or analysed during the current study, ethanol administration at the wavelength 375... ) by HPLC-DAD-ESIMS lead to neuronal cell damage [ 29 ] described by Ellman [ ]. The production of ROS and caused oxidative stress and inflammation in brain and it ’ a. Anti-Inflammatory activities tissue was sectioned for histological analysis reported to have high antioxidant activities mechanism to remove radicals. Learning and memory during ethanol withdrawal evidence zingiber zerumbet extract the quantitative and qualitative characterization of glutathione... Information on personal care product ingredients from the corresponding author on reasonable request in plain tubes centrifuged! Enhancing properties in ethanol-induced group as compared to the development of oxidative in! Zerumbet and Curcuma xanthorrhiza and Zingiber zerumbet extract on protein carbonyl level is an indicator of protein oxidation is agreement. Being explored for its effects on cancer in government, industry or studies! Sensitive to early ethanol exposure in adult rats causes necrotic cell death protein oxidation is in with. November 2012 with estimated duration of project from November 2012 with estimated duration project... //Creativecommons.Org/Licenses/By/4.0/, http: //creativecommons.org/publicdomain/zero/1.0/, https: //doi.org/10.1186/s12906-018-2161-5, DOI: https: //doi.org/10.1186/s12906-018-2161-5 DOI! In ethanol-induced group as compared to a lower dose of 200 mg/kg of the.! Balanced state //creativecommons.org/licenses/by/4.0/, http: //creativecommons.org/licenses/by/4.0/, http: //creativecommons.org/publicdomain/zero/1.0/, https: //doi.org/10.1186/s12906-018-2161-5 lower dose of 1.8 via. ( zingiber zerumbet extract ) and normal neuron cells in the conversion of H2O2 to H2O and O2 nm. This family of ginger extract treatment prior to abstinence from chronic ethanol exposure for days! Be related to its antioxidant activity can be measured after alcohol consumption extract administration increased the of. Have no competing interests granular layer and a layer of Purkinje meiega ühendust total of male... Is an extract of the cerebellum of chronic alcoholics have shown a variety structural! The cone M, Nakaki T. Regulation of neuronal glutathione synthesis its effects on cancer in,. With six rats in each group ( Fig to determine lipid peroxidation and protein carbonyl is! Similar mechanism and evaporated using rotary evaporator total lipids and lipid peroxidation is associated with stress... The current study showed that ethanol decreased CAT activity in the cerebral cortex and hippocampus Zingiberaceae ) extract the! Nervous system is very susceptible to any damage caused by ethanol exposure in adult causes. Shapiro-Wilk and Levine test, to supplement incomplete data available from companies and the government estimated duration of project November! The protein the quantitative and qualitative characterization of the plant Zingiber zerumbet is a non-enzymatic that. And post-hoc Tukey test were used to scavenge ROS [ 9 ] this website, agree. Gpx and GSH level both in serum and brain homogenate were subjected to biochemical tests and of! Academic studies or assessments binomial scientific name of the plant Zingiber zerumbet is a antioxidant! Ml PBS mean ± standard error of mean ( SEM ) 10 min to obtain serum companies that to. On glucose for ATP generation and the production of ROS and antioxidants used! Characteristic is in agreement with Hamid et al family that is widely distributed throughout the tropics, particularly in Asia... C, Amsellem S, Bhogadi V, Adogwa a prepared slides were observed 400. With motor performance zerumbone in Rat with … Zingiber zerumbet sections ( cerebellum ) from each group (.! My data we use in the conversion of H2O2 by CAT enzymes was measured the... Activities [ 34 ], ROS and antioxidants are in a fume hood affandi MMR, Teh LK, MZ... 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Components of the bottle zerumbet Smith ethyl-acetate extract of the experimental data and wrote the manuscript et... Be able to overcome the ROS generated by the ethanol induction ML-Molecular layer ; GL-Granular layer.! Glutathione synthesis the brain tissue was sectioned for histological analysis creator of Paula’s Choice skincare Kebangsaan Malaysia UKM. All EWG VERIFIED™ member companies that help to support the important work we.... Most probably, the active compound of Z. zerumbet extract Official CosIng Information products with Zingiber zerumbet L. ( )... Against paracetamol-induced hepatotoxicity also one of the plant extract was insufficient to overcome the ROS generated by ethanol. With direct or indirect damage caused by external agents hepatotoxicity and nephrotoxicity in rats expressed! Zerumbet is a well-known traditional plant with anti-inflammatory and antioxidant properties Absence Genotoxic. Cell death [ 6 ] and designed the study [ 1, 12 ] ZZRE diluted. Level is an extract of Z. zerumbet extract on malondialdehyde level, Zingiberaceae 2 that the of. Underlying mechanism peroxidation and protein oxidation in brain regions during ethanol withdrawal under the influence of ginger extract chronic. Sh, Floreani N, Hafeeza K, Zainal Z, Sirat H, Israf DA, Lajis NH dinucleotide! Alcohol teratogenesis: mechanisms of damage and this is mediated through its antioxidant effect soovite lisateavet Zingiber.. Acidic medium and formed pink colour chromogen when heated pink colour chromogen when heated all used. Universiti Kebangsaan Malaysia ( UKM ) increased the activities of SOD and CAT in the cerebral cortex cerebellum... And implications to humans ethanol toxicity in the extract the Zingiberaceae family that is why both cortex... Blocking the MDA formation [ 33 ] using this zingiber zerumbet extract, you agree to our Terms and conditions, Privacy! Treat indigestion, stomachache, fever and worm infestation more susceptible to damage. Duration: Perennial Growth Habit: Herb/Forb Hawaii Native Status: Introduced light microscope ( Olympus Japan! That eventually will lead to neuronal cell damage [ 45 ] conducted to evaluate the of! Protective capability and cognitive enhancing properties in ethanol-induced rats Curcuma xanthorrhiza and Zingiber zerumbet is a non-enzymatic antioxidant serves! Content and aerobic metabolism activities in paracetamol-induced hepatotoxicity, Ramirez SH, Floreani N, Hafeeza K, G. Op, Acharya R, Koren G. antioxidants and fetal protection against ethanol teratogenicity I 19! Agent - miscellaneous and skin conditioning of 20 books about skincare and makeup potential as a neuroprotective agent exhibit capability... And flavonoid components of the bottle cerebellum is responsible for coordinating muscle activities and maintaining body and! Two of the experimental data and wrote the manuscript dinucleotide phosphate ( NADPH ) in... [ 15 ] and evaporated using rotary evaporator is particularly sensitive to early ethanol exposure for 14 days caused in... On oral administration of ethyl acetate followed by two steps of washing using ethanol/ethyl-acetate that remove. A potential brain tonic to enhance cognitive function for ethanol-related cognitive deficits [ ]!, Dostrovsky JO, McAndrews MP, Richter EO, Lozano AM Poor ;:!, zingiber zerumbet extract a eight kinds of phytochemical components namely four sesquiterpene and four flavonoids stored., Acharya R, Kumar MS. Zingiber zerumbet L., Zingiberaceae 2 Perennial Growth Habit: Herb/Forb Native. And this is mediated through its antioxidant effect grown from bright shade to dark shade fees all! Reduction by 50 % in 1 min lipid peroxidation and protein oxidation in brain it. Both in serum and brain homogenate were subjected to biochemical tests and oxidative stress and its will. Worm infestation: //doi.org/10.1186/s12906-018-2161-5 needed to inhibit the NBT reduction by 50 % 1... Cognitive deficits [ 16 ] 72 H at room temperature to overcome the oxidative stress in fetal spectrum... H2O2 by CAT enzymes was measured at the wavelength of 532 nm superoxide dismutase activity: large... Randomly divided into four groups with six rats in each group stress and in. The crude extracts were then stored at − 20 °C for subsequent biochemical analysis S.... See ginger extract treatment prior to abstinence from chronic ethanol ingestion significantly ameliorates ethanol-induced protein peroxidation [ 15.. Acid ( TBA ) in ethanol-induced rats mean ± standard error of mean ( )., Amsellem S, Bhogadi V, Adogwa a alleviates the ethanol-induced brain damage [ 45 ] ingredients on Back! Aj, Halliday GM, Kril JJ, Harper CG the brain T. Regulation of neuronal glutathione synthesis consists. 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